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1

National Academies report has broad support

Vincelli, Paul, Jackson-Smith, Douglas, Holsapple, Michael, Grusak, Michael A, Harsh, Matthew, Klein, Theodore, Lambert, James, Lange, B Markus, Lodge, David M, McCluskey, Jill, Murphy, Angus, Neuhous

Journal:

Nature Biotechnology

Year:

2017

Language:

english

File:

PDF, 115 KB

english, 2017

2

Role of metabolism in dimethylnitrosamine-induced immunosuppression: a review

Helen G. Haggerty, Michael P. Holsapple

Journal:

Year:

1990

Language:

english

File:

PDF, 1.30 MB

english, 1990

3

10.1038/45985

Housen, Kevin R., Holsapple, Keith A., Voss, Michael E.

Journal:

Year:

1999

Language:

english

File:

PDF, 175 KB

english, 1999

4

Species comparison of anatomical and functional immune system development

Michael P. Holsapple, Lori J. West, Kenneth S. Landreth

Journal:

Birth Defects Research Part B: Developmental and Reproductive Toxicology

Year:

2003

Language:

english

File:

PDF, 168 KB

english, 2003

5

Strategies for the follow-up of positive results in the in vitro genotoxicity assays—An international collaborative initiative

B. Bhaskar Gollapudi, Véronique Thybaud, James H. Kim, Michael Holsapple

Journal:

Environmental and Molecular Mutagenesis

Year:

2011

Language:

english

File:

PDF, 47 KB

english, 2011

6

Reversible depression of electrically-induced contractions of guinea pig longitudinal muscle by a reversible inhibitor of prostaglandin synthetase

Michael P. Holsapple, Donald E. Blake, George K.W. Yiml

Journal:

Prostaglandins and Medicine

Year:

1979

Language:

english

File:

PDF, 444 KB

english, 1979

7

Effects of subchronic exposure to diethylstilbestrol on humoral immune function in adult female (C3B6)F1 mice

Peter H. Bick, Anne N. Tucker, Kimber L. White Jr., Michael P. Holsapple

Journal:

Immunopharmacology

Year:

1984

Language:

english

File:

PDF, 922 KB

english, 1984

8

Immunosuppression by polycyclic aromatic hydrocarbons: A structure-activity relationship in B6C3F1 and DBA/2 mice

Kimber L. White Jr., Helen H. Lysy, Michael P. Holsapple

Journal:

Immunopharmacology

Year:

1985

Language:

english

File:

PDF, 744 KB

english, 1985

9

Direct suppression of antibody responses by chlorinated dibenzodioxins in cultured spleen cells from (C57BL/6 × C3H)F1 and DBA/2 mice

Michael P. Holsapple, Robert K. Dooley, Peter J. McNerney, J. Ann McCay

Journal:

Immunopharmacology

Year:

1986

Language:

english

File:

PDF, 923 KB

english, 1986

10

Primary cellular target responsible for dimethylnitrosamine-induced immunosuppression in the mouse

Kirk W. Johnson, Albert E. Munson, Michael P. Holsapple

Journal:

Immunopharmacology

Year:

1987

Language:

english

File:

PDF, 1.08 MB

english, 1987

11

Elucidation of cellular targets responsible for tetrachlorodibenzo-p-dioxin (TCDD)-induced suppression of antibody responses: I. The role of the B lymphocyte

Robert K. Dooley, Michael P. Holsapple

Journal:

Immunopharmacology

Year:

1988

Language:

english

File:

PDF, 1.01 MB

english, 1988

12

Elucidation of cellular targets responsible for tetrachlorodibenzo-p-dioxin (TCDD)-induced suppression of antibody responses: II. The role of the T-lymphocyte

Robert K. Dooley, Dale L. Morris, Michael P. Holsapple

Journal:

Immunopharmacology

Year:

1990

Language:

english

File:

PDF, 922 KB

english, 1990

13

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on humoral immunity: I. Similarities to Staphylococcus aureus Cowan Strain I (SAC) in the in vitro T-dependent antibody response

Dale L. Morris, Stephen D. Jordan, Michael P. Holsapple

Journal:

Immunopharmacology

Year:

1991

Language:

english

File:

PDF, 978 KB

english, 1991

14

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on humoral immunity: II. B cell activation

Dale L. Morris, Michael P. Holsapple

Journal:

Immunopharmacology

Year:

1991

Language:

english

File:

PDF, 941 KB

english, 1991

15

Direct effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on responses to lipopolysaccharide (LPS) by isolated murine B-cells

Dale L. Morris, James G. Karras, Michael P. Holsapple

Journal:

Immunopharmacology

Year:

1993

Language:

english

File:

PDF, 663 KB

english, 1993

16

A functional characterization of macrophage alterations in casein-treated B6C3F1 mice

Norbert E. Kaminski, Michael P. Holsapple

Journal:

Immunopharmacology

Year:

1992

Language:

english

File:

PDF, 1.06 MB

english, 1992

17

Immunosuppression in adult female B6C3F1 mice by chronic exposure to ethanol in a liquid diet

Michael P. Holsapple, Micah Eads, Wayne D. Stevens, Steve C. Wood, Norbert E. Kaminski, Dale L. Morris, Alphonse Poklis, Edward J. Kaminski, Stephen D. Jordan

Journal:

Immunopharmacology

Year:

1993

Language:

english

File:

PDF, 1.87 MB

english, 1993

18

Serum modulation of the effects of TCDD on the in vitro antibody response and on enzyme induction in primary hepatocytes

Dale L. Morris, Hye G. Jeong, Wayne D. Stevens, Young J. Chun, James G. Karras, Michael P. Holsapple

Journal:

Immunopharmacology

Year:

1994

Language:

english

File:

PDF, 1.08 MB

english, 1994

19

Role of metabolism in cocaine-induced immunosuppression in splenocyte cultures from B6C3F1 female mice

Tae Cheon Jeong, Ray A. Matulka, Stephen D. Jordan, Kyu-Hwan Yang, Michael P. Holsapple

Journal:

Immunopharmacology

Year:

1995

Language:

english

File:

PDF, 943 KB

english, 1995

20

Characterization of the delayed hypersensitivity response to a protein antigen in the mouse—I. Kinetics of reactivity and sensitivity to classical immunosuppressants

Michael P. Holsapple, Dennis G. Page, Peter H. Bick, George M. Shopp

Journal:

International Journal of Immunopharmacology

Year:

1984

Language:

english

File:

PDF, 591 KB

english, 1984

21

A review of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced changes in immunocompetence: 1991 update

Michael P. Holsapple, Neil K. Snyder, Steven C. Wood, Dale L. Morris

Journal:

Year:

1991

Language:

english

File:

PDF, 2.53 MB

english, 1991

22

The effects of acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on glioma-specific cytotoxic T-cell activity in Fischer 344 rats

Charles D. Rice, Randall E. Merchant, Tae Cheong Jeong, James B. Karras, michael P. Holsapple

Journal:

Year:

1995

Language:

english

File:

PDF, 897 KB

english, 1995

23

Velocity scaling impact melt volume

Michael D. Bjorkman, Keith A. Holsapple

Journal:

International Journal of Impact Engineering

Year:

1987

Language:

english

File:

PDF, 534 KB

english, 1987

24

Developmental immunotoxicity testing: a review

Michael P Holsapple

Journal:

Year:

2003

Language:

english

File:

PDF, 447 KB

english, 2003

25

Effects of flow rate on high-throughput quantitative analysis of protein-precipitated plasma using liquid chromatography/tandem mass spectrometry

Anthony T. Murphy, Michael J. Berna, Jeffrey L. Holsapple, Bradley L. Ackermann

Journal:

Rapid Communications in Mass Spectrometry

Year:

2002

Language:

english

File:

PDF, 150 KB

english, 2002

26

Therapeutic reduction of ongoing carrageenin-induced inflammation by lipoxygenase, but not cyclooxygenase inhibitors

Michael P. Holsapple, George K. W. Yim

Journal:

Year:

1984

Language:

english

File:

PDF, 362 KB

english, 1984

27

Pharmacological modulation of edema mediated by prostaglandin, serotonin and histamine

Michael P. Holsapple, Marilyn Schnur, George K. W. Yim

Journal:

Inflammation Research

Year:

1980

Language:

english

File:

PDF, 452 KB

english, 1980

28

Reduction of aspirin-induced ulcers by a new imidazoline anti-inflammatory agent

Michael P. Holsapple, Alexa Chun, Ralph W. Lagally, David E. Nichols, George K. W. Yim

Journal:

Inflammation Research

Year:

1981

Language:

english

File:

PDF, 370 KB

english, 1981

29

Importance of hepatocyte culture conditions in dimethylnitrosamine-induced suppression of antibody response in the mixed cultures of murine hepatocytes and splenocytes

Tae-Cheon Jeong, Kyu-Hwan Yang, Michael P. Holsapple

Journal:

Year:

1992

Language:

english

File:

PDF, 783 KB

english, 1992

30

Direct effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on human tonsillar lymphocytes

Steven C. Wood, Hye Gwang Jeong, Dale L. Morris, Michael P. Holsapple

Journal:

Year:

1993

Language:

english

File:

PDF, 819 KB

english, 1993

31

Role of hydrocortisone in dimethylnitrosamine-induced suppression of antibody response in the mixed culture of murine hepatocytes and splenocytes

Tae Cheon Jeong, Kyu-Hwan Yang, Stephen D. Jordan, Wayne D. Stevens, Michael P. Holsapple

Journal:

Year:

1994

Language:

english

File:

PDF, 989 KB

english, 1994

32

Disruption of Th1/Th2 cytokine balance by cocaine is mediated by corticosterone

Eric D Stanulis, Stephen D Jordan, John A Rosecrans, Michael P Holsapple

Journal:

Immunopharmacology

Year:

1997

Language:

english

File:

PDF, 358 KB

english, 1997

33

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Elevates Basal B-Cell Intracellular Calcium Concentration and Suppresses Surface Ig- but Not CD40-Induced Antibody Secretion

James G. Karras, Dale L. Morris, Ray A. Matulka, Caroline M. Kramer, Michael P. Holsapple

Journal:

Toxicology and Applied Pharmacology

Year:

1996

Language:

english

File:

PDF, 243 KB

english, 1996

34

Cytokine Profiling and Chemical Allergy: Re: Plitnick, L. M., Loveless, S. E., Ladics, G. S., Holsapple, M. P., Selgrade, M. J., Sailstad, D. M., and Smialowicz, R. J. (2002). Cytokine profiling for chemical sensitizers: Application of the ribonuclease protection assay and effect of dose. Toxicology and Applied Pharmacology179, 145–154, Reply

Lisa M. Plitnick, Michael P. Holsapple, Scott E. Loveless, Gregory S. Ladics, MaryJane Selgrade, Denise M. Sailstad, Ralph J. Smialowicz

Journal:

Toxicology and Applied Pharmacology

Year:

2002

Language:

english

File:

PDF, 21 KB

english, 2002

35

Production of DNA single-strand breaks in unstimulated splenocytes by dimethylnitrosamine

Byung-Sam Kim, Kyu-Hwan Yang, Helen G. Haggerty, Michael P. Holsapple

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1989

Language:

english

File:

PDF, 708 KB

english, 1989

36

Immunosuppression without liver induction by subchronic exposure to 2,7-dichlorodibenzo-p-dioxin in adult female B6C3F1 mice

Michael P. Holsapple, J.Ann McCay, Donald W. Barnes

Journal:

Toxicology and Applied Pharmacology

Year:

1986

Language:

english

File:

PDF, 926 KB

english, 1986

37

The role of metabolism in carbon tetrachloride-mediated immunosuppression: In vivo studies

Norbert E. Kaminski, Donald W. Barnes, Stephen D. Jordan, Michael P. Holsapple

Journal:

Toxicology and Applied Pharmacology

Year:

1990

Language:

english

File:

PDF, 3.08 MB

english, 1990

38

Dependence on intact cells for the in vitro activation of dimethylnitrosamine to an immunosuppressive form

Kirk W. Johnson, Dong-Hyun Kim, Albert E. Munson, Michael P. Holsapple

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Year:

1987

Language:

english

File:

PDF, 972 KB

english, 1987

39

Symposium summary: Children's Health Risk—What's So Special about the Developing Immune System?

Michael P Holsapple, Dennis J Paustenbach, Gail Charnley, Lori J West, Michael I Luster, Rodney R Dietert, Leigh Ann Burns-Naas

Journal:

Toxicology and Applied Pharmacology

Year:

2004

Language:

english

File:

PDF, 399 KB

english, 2004

40

Evaluating emerging issues in epidemiology

James J. Collins, John A. Bukowski, Douglas L. Weed, Robert L. Brent, Patti Klein, Mariette Boerstoel-Streefland, J. Michael Sprafka, Amy Lavin Williams, Michael P. Holsapple

Journal:

Regulatory Toxicology and Pharmacology

Year:

2007

Language:

english

File:

PDF, 209 KB

english, 2007

41

Effects of 7,12-dimethylbenz[a]anthracene on the superantigen toxic shock syndrome toxin (TSST-1)-induced proliferation and antibody secretion by human lymphocytes

Steven C. Wood, Michael P. Holsapple

Journal:

Fundamental and Applied Toxicology

Year:

1993

Language:

english

File:

PDF, 890 KB

english, 1993

42

Lack of direct effect of 2,3,7,8-tetrachlorodibenzo-P-dioxin (TCDD) on Protein Kinase C activity in EL4 cells

Caroline M. Kramer, Julianne J. Sando, Michael P. Holsapple

Journal:

Biochemical and Biophysical Research Communications

Year:

1986

Language:

english

File:

PDF, 345 KB

english, 1986

43

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) enhances antibody production and protein kinase activity in murine B cells

Caroline M. Kramer, Kirk W. Johnson, Robert K. Dooley, Michael P. Holsapple

Journal:

Biochemical and Biophysical Research Communications

Year:

1987

Language:

english

File:

PDF, 496 KB

english, 1987

44

Role of the transfer of metabolites from hepatocytes to splenocytes in the suppression of in vitro antibody response by dimethylnitrosamine

Kim Dong-Hyun, Yang Kyu-Hwan, Kirk W. Johnson, Michael P. Holsapple

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 862 KB

english, 1988

45

Mechanisms of in vitro immunosuppression by hepatocyte-generated cyclophosphamide metabolites and 4-hydroperoxycyclophosphamide

Thomas T. Kawabata, Monica Y. Chapman, Kim Dong-Hyun, Wayne D. Stevens, Michael P. Holsapple

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 1.05 MB

english, 1990

46

Identification of functional aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator in murine splenocytes

Courtney E. Williams, Robert B. Crawford, Michael P. Holsapple, Norbert E. Kaminski

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.19 MB

english, 1996

47

Framework for use of toxicity screening tools in context-based decision-making

John Doull, Joseph F. Borzelleca, Richard Becker, George Daston, John DeSesso, Anna Fan, Penelope Fenner-Crisp, Michael Holsapple, Joseph Holson, G. Craig Llewellyn, James MacGregor, Jennifer Seed, Is

Journal:

Food and Chemical Toxicology

Year:

2007

Language:

english

File:

PDF, 475 KB

english, 2007

48

Scientific advancement of novel protein allergenicity evaluation: An overview of work from the HESI Protein Allergenicity Technical Committee (2000–2008)

Karluss Thomas, Sue MacIntosh, Gary Bannon, Corinne Herouet-Guicheney, Michael Holsapple, Gregory Ladics, Scott McClain, Stefan Vieths, Michael Woolhiser, Laura Privalle

Journal:

Food and Chemical Toxicology

Year:

2009

Language:

english

File:

PDF, 222 KB

english, 2009

49

Relevance and follow-up of positive results in in vitro genetic toxicity assays: An ILSI-HESI initiative

Véronique Thybaud, Marilyn Aardema, Daniel Casciano, Vicki Dellarco, Michelle R. Embry, B. Bhaskar Gollapudi, Makoto Hayashi, Michael P. Holsapple, David Jacobson-Kram, Peter Kasper, James T. MacGrego

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2007

Language:

english

File:

PDF, 172 KB

english, 2007

50

Methodologies for developmental immunotoxicity (DIT) testing

Rodney R. Dietert, Michael P. Holsapple

Journal:

Year:

2007

Language:

english

File:

PDF, 311 KB

english, 2007

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